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Dermorphin 5mg(Dermorphin Heptapeptide D-Ala²)
(Heptapeptide–7 Amino Acids)
( Product no. 871-87 )
£26.99
Naturally Derived Short Chain Opioid Peptide Studied in Receptor Binding Research
Dermorphin is a naturally occurring opioid heptapeptide recognised in peptide research for its distinctive sequence and strong mu-opioid receptor binding profile. It is studied in laboratory settings for receptor selectivity, ligand binding behaviour, signalling activity, and structure activity relationships. Researchers also examine Dermorphin in comparative peptide work focused on molecular recognition, sequence function, and receptor targeted assay development within opioid peptide science.
Dermophine 5mg
(Dermorphin Heptapeptide)
Premium Grade | UK Supply
Product Overview
Dermorphine is a naturally derived opioid heptapeptide originally identified in amphibian skin secretions and subsequently produced for laboratory work via controlled peptide synthesis and purification. In research settings it is supplied as a defined sequence reference material for studies that require a high affinity ligand in opioid receptor model systems. Dermorphine is examined for its strong and selective binding behaviour in mu opioid receptor assays, making it useful in experiments that compare ligand affinity, receptor activation profiles, and signalling bias across peptide and non peptide opioid ligands. Supplied in lyophilised form, it supports controlled reconstitution and concentration accuracy for repeatable in vitro use, including receptor binding studies and analytical validation workflows.
Scientific Background
From a molecular science perspective, Dermorphine is notable for its D amino acid feature at position 2 (D Ala), a structural characteristic associated with altered protease susceptibility and enhanced receptor binding behaviour in experimental systems. The peptide sequence is Tyr D Ala Phe Gly Tyr Pro Ser NH2 and is examined as a high affinity mu opioid receptor agonist in controlled receptor models. Research focuses on ligand receptor contact geometry, hydrogen bonding networks, and conformational constraints that influence activation efficiency and downstream signal routing. Dermorphine is also used in studies exploring receptor phosphorylation patterns, beta arrestin recruitment logic, and receptor internalisation kinetics, helping researchers map how peptide ligands can produce distinct signalling fingerprints compared with small molecule agonists within standardised assay conditions.
Research Applications
Dermorphine is extensively researched in receptor pharmacology and molecular signalling studies using in vitro systems that express mu opioid receptors, including engineered cell lines, membrane preparations, and reporter based assay formats. It is used to investigate binding affinity, competitive displacement behaviour, and concentration response relationships, as well as to characterise pathway specific readouts such as G protein linked signalling, cAMP modulation models, and downstream kinase activation patterns in controlled experimental designs. Dermorphine is also applied in comparative ligand bias studies, where its signalling profile is assessed against other opioid peptides to evaluate functional selectivity, desensitisation dynamics, and receptor trafficking outcomes. In analytical research, it supports LC MS method development, stability evaluation, and impurity profiling, assisting laboratories with identity confirmation and batch consistency assessment under reproducible laboratory conditions.
Technical Specifications
- Contents: 5mg Dermorphine
- Form: Lyophilised powder
- Purity: >99% (HPLC verified)
- Molecular Formula: C₄₀H₅₀N₈O₁₀
- Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂
- Peptide Length: 7 amino acids
- pH Range: 6.0-7.1
- Storage: Store between 1°C - 5°C
Note: Reconstitute with Bacteriostatic (BAC) water for best results.
Related Research Compounds
ACE-031 1mg
Melatonin 10mg
Kisspeptine 10mg
Internal Research Sources
Trade supply
Peptide sets
Bulk purchase range
Disclaimer
Dermorphin is a naturally occurring opioid heptapeptide recognised in peptide research for its distinctive sequence and strong mu-opioid receptor binding profile. It is studied in laboratory settings for receptor selectivity, ligand binding behaviour, signalling activity, and structure activity relationships. Researchers also examine Dermorphin in comparative peptide work focused on molecular recognition, sequence function, and receptor targeted assay development within opioid peptide science.
Dermophine 5mg
(Dermorphin Heptapeptide)
Premium Grade | UK Supply
Product Overview
Dermorphine is a naturally derived opioid heptapeptide originally identified in amphibian skin secretions and subsequently produced for laboratory work via controlled peptide synthesis and purification. In research settings it is supplied as a defined sequence reference material for studies that require a high affinity ligand in opioid receptor model systems. Dermorphine is examined for its strong and selective binding behaviour in mu opioid receptor assays, making it useful in experiments that compare ligand affinity, receptor activation profiles, and signalling bias across peptide and non peptide opioid ligands. Supplied in lyophilised form, it supports controlled reconstitution and concentration accuracy for repeatable in vitro use, including receptor binding studies and analytical validation workflows.
Scientific Background
From a molecular science perspective, Dermorphine is notable for its D amino acid feature at position 2 (D Ala), a structural characteristic associated with altered protease susceptibility and enhanced receptor binding behaviour in experimental systems. The peptide sequence is Tyr D Ala Phe Gly Tyr Pro Ser NH2 and is examined as a high affinity mu opioid receptor agonist in controlled receptor models. Research focuses on ligand receptor contact geometry, hydrogen bonding networks, and conformational constraints that influence activation efficiency and downstream signal routing. Dermorphine is also used in studies exploring receptor phosphorylation patterns, beta arrestin recruitment logic, and receptor internalisation kinetics, helping researchers map how peptide ligands can produce distinct signalling fingerprints compared with small molecule agonists within standardised assay conditions.
Research Applications
Dermorphine is extensively researched in receptor pharmacology and molecular signalling studies using in vitro systems that express mu opioid receptors, including engineered cell lines, membrane preparations, and reporter based assay formats. It is used to investigate binding affinity, competitive displacement behaviour, and concentration response relationships, as well as to characterise pathway specific readouts such as G protein linked signalling, cAMP modulation models, and downstream kinase activation patterns in controlled experimental designs. Dermorphine is also applied in comparative ligand bias studies, where its signalling profile is assessed against other opioid peptides to evaluate functional selectivity, desensitisation dynamics, and receptor trafficking outcomes. In analytical research, it supports LC MS method development, stability evaluation, and impurity profiling, assisting laboratories with identity confirmation and batch consistency assessment under reproducible laboratory conditions.
Technical Specifications
- Contents: 5mg Dermorphine
- Form: Lyophilised powder
- Purity: >99% (HPLC verified)
- Molecular Formula: C₄₀H₅₀N₈O₁₀
- Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂
- Peptide Length: 7 amino acids
- pH Range: 6.0-7.1
- Storage: Store between 1°C - 5°C
Note: Reconstitute with Bacteriostatic (BAC) water for best results.
Related Research Compounds
ACE-031 1mg
Melatonin 10mg
Kisspeptine 10mg
Internal Research Sources
Trade supply
Peptide sets
Bulk purchase range
Disclaimer
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How to Reconstitute Your Peptides
What You Will Need
- Lyophilized peptide vial
- Sterile solvent (such as bacteriostatic water or another suitable choice)
- 1 ml sterile syringe with a fine (29–30g) needle
- Sterile alcohol wipes
- Calculator for dilution and dosage accuracy
- Labels for marking each aliquot with concentration and date
- Sterile workspace or biosafety cabinet (recommended for best practice)
Preparation Steps
Allow the vial to reach room temperature
This helps prevent condensation, which can compromise sterility when you open the vial.
Draw up the solvent
Using a sterile syringe, measure the precise amount of bacteriostatic water or your chosen solvent.
Inject the solvent gently
Insert the needle into the vial at a 45-degree angle so the liquid runs down the inside wall, which reduces bubbling and foam.
Dissolve the peptide
Swirl the vial gently until the peptide powder is completely dissolved. Avoid shaking, as this can damage the peptide bonds.
Aliquot the solution
If smaller, single-use portions are needed, divide the solution into sterile microtubes using a new, sterile syringe or pipette for each.
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Tips for Storing Your Peptides
General Storage Guidelines
- Store all peptides in airtight, moisture-resistant containers to prevent exposure to humidity.
- Minimise freeze-thaw cycles by dividing peptides into single-use aliquots whenever possible.
- Protect peptides from light, especially if they are modified or known to be photosensitive, by storing them in amber vials or wrapping them in foil.
- Always practice sterile handling and accurate labelling, including peptide name, concentration, date, and storage conditions.
Lyophilised Peptides
- Keep lyophilised (freeze-dried) peptides at minus 20°C or lower for long-term stability.
- Ensure the container is sealed tightly to keep out moisture.
- Allow the vial to reach room temperature before opening to avoid condensation, which can degrade the peptide.
- Only open vials in a dry environment to prevent humidity from affecting the product.
Reconstituted Peptides
- Store peptides reconstituted with sterile water or buffer at 2°C to 8°C and use within 1–12 weeks.
- If peptides are dissolved in DMSO or other organic solvents, store them at minus 20°C and protect from light.
- Always aliquot into single-use volumes immediately after reconstitution to avoid repeated freeze-thaw cycles.
- Clearly label all aliquots with relevant information and only thaw as needed to preserve the peptide’s activity and integrity.
Read More on Storage Guidelines
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If you have any questions regarding our research peptides for sale, please feel free to reach out below.
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Shipping and Postage
UK & European Delivery
Evri UK Tracked 1-2 Business Days
This costs; £4.99 per order
European DHL Express Tracked 1-2 Days
This cost; £24.99 per order
Bioplex Peptides offers fast and reliable 1-2 days delivery across the UK with full tracking included. Note; Due to the nature of our products, we only dispatch samples between Monday-Thursday, orders after 12pm will be shipped the following day.
*We aim to dispatch and deliver orders within the stated timeframes, but delays can occur due to severe weather, transport issues, public holidays, or other unforeseen events. Once an order has been dispatched, extended delivery times are outside our control.
International Delivery
United States of America & Canada 1-2 Business Days
This cost; £24.99 per order
International Delivery 1-3 Business Days
This cost; £29.99 per order
Bioplex Peptides offers fast and reliable 1-3 days worldwide delivery with full tracking included using the worlds fastest and most reliable courier available with a discounted rate for all EU & International customers. Delays may occur due to natural causes such as severe weather conditions, transportation disruptions, public holidays, or other unforeseen events. All international samples ship Monday–Saturday, ensuring steady worldwide delivery scheduling.
Order Processing
Orders are typically processed within 24hrs after payment confirmation. Custom peptide synthesis orders and wholesale orders may require additional lead time depending on complexity and quantity. Clients will be notified of estimated delivery timelines upon order confirmation.
Shipping Methods and Carriers
We utilize reliable courier services such DHL Express Premium 1-2 Business days for all International deliveries and Evri & Royal Mail tracked 1-2 days delivery for all United Kingdom deliveries to ensure timely and traceable delivery. Shipping options may vary depending on destination, order size, and regulatory requirements.
BioPleX Peptides is not responsible for delays caused by customs clearance, weather disruptions, or carrier-related issues.
Returns and Refunds
Due to the specialised and perishable nature of our research peptide products, BioPlex Peptides does not offer general refunds or accept returns once an order has been shipped. All purchases are considered final unless they meet specific criteria outlined below.
Refunds and Replacements
We do not provide refunds for products that have been correctly fulfilled and delivered. However, if an item arrives damaged, compromised, or incorrect due to an error on our part, we will offer a replacement at no additional cost. Claims must be submitted within 48 hours of delivery, accompanied by photographic evidence and a description of the issue.
Missing Parcels
If your parcel has not arrived within the estimated delivery window, please contact our logistics team promptly. We will initiate an investigation with the carrier and provide updates throughout the process. If the parcel is confirmed lost, we will issue a replacement shipment or credit, depending on the circumstances.
Order Cancellation
Orders may be cancelled within 24 hours of placement, provided production has not yet begun. Custom peptide synthesis orders are non-cancellable once processing has started. To request a cancellation, please email us at enquiries@bioplexpeptides.co.uk with your order number and reason for cancellation.
Damaged or Incorrect Items
In the rare event that you receive a damaged or incorrect item, please notify us within 48 hours of receipt. Include your order number, photos of the product and packaging, and a description of the issue. We will assess the claim and, if validated, arrange for a replacement to be shipped promptly.
Read More on Our Returns & Refunds Policy
Ask a Question
If you have any questions regarding our research peptides for sale, please feel free to reach out below.
Quick Links
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